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Childhood acute lymphoblastic leukaemia: outcomes of 54 consecutive patients treated in Auckland 1985-1991
1Starship Children's Health, Auckland.
Insights
Childhood acute lymphoblastic leukaemia survival rates in Auckland between 1985-1991 were 75% for overall survival and 60% for event-free survival using an international protocol.
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Trials
Background:
- Acute lymphoblastic leukaemia (ALL) is a common childhood cancer.
- International treatment protocols aim to standardize care and improve outcomes.
- Assessing outcomes in specific geographic regions is crucial for evaluating treatment effectiveness.
Purpose of the Study:
- To report survival and event-free survival for children with ALL treated in Auckland.
- To evaluate outcomes using the ANZCCSG ALL Study V international protocol.
- To compare local outcomes with international benchmarks.
Main Methods:
- Prospective data collection as part of the ANZCCSG ALL Study V.
- Application of standard survival analysis methods.
- Median follow-up of 7.5 years for the study cohort.
Main Results:
- Overall survival rate of 75% was achieved.
- Event-free survival rate was 60%.
- Outcomes were comparable to international series for an unselected patient group.
Conclusions:
- The treatment protocol yielded comparable survival rates to international standards.
- Similar survival outcomes are anticipated for children diagnosed in the 1990s.
- This study provides valuable data on childhood ALL treatment efficacy in Auckland.
Aims:
To report the survival and event-free survival of children with acute lymphoblastic leukaemia treated in Auckland between 1985-1991, using an international protocol, ANZCCSG ALL Study V.
Methods:
The data were collected prospectively as part of the study. The analysis was carried out using standard survival methods.
Results:
At a median follow up of 7.5 years, the overall survival is 75% and event-free survival 60%.
Conclusions:
For an unselected series, these outcomes are comparable to overseas series. The survival for children diagnosed in the 1990's is likely to be similar.