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Related Experiment Videos

Equine sarcoids

L Goodrich1, H Gerber, E Marti

  • 1College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

The Veterinary Clinics of North America. Equine Practice
|January 19, 1999
PubMed
Summary

Equine sarcoids are common, invasive skin tumors in horses, likely caused by bovine papilloma viruses. Genetic factors and viral causes influence susceptibility and treatment, highlighting the need for future preventative strategies.

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Area of Science:

  • Veterinary Dermatology
  • Equine Neoplastic Disease

Background:

  • Sarcoids are the most common skin tumors in horses, presenting as fibroblastic, wart-like lesions.
  • These tumors can be invasive and recurrent, potentially causing loss of use in horses due to their location.
  • Strong evidence links equine sarcoids to bovine papilloma viruses, with genetic associations found near the equine major histocompatibility complex (MHC).

Purpose of the Study:

  • To summarize the current understanding of equine sarcoids, including their cause, clinical presentation, and treatment.
  • To highlight the etiological factors, such as viral involvement and genetic predisposition.
  • To discuss the challenges in treatment and potential future directions for prevention.

Main Methods:

  • Review of existing literature on equine sarcoids.
  • Analysis of etiological evidence, including viral and genetic factors.
  • Summary of therapeutic approaches and outcomes.

Main Results:

  • Equine sarcoids are strongly associated with papillomaviruses, similar to those found in cattle.
  • Genetic susceptibility to sarcoids is linked to genes within or near the equine MHC.
  • Current treatments for sarcoids show variable success rates.

Conclusions:

  • Equine sarcoid etiology involves both viral agents and host genetic factors.
  • Effective treatment remains challenging due to inconsistent responses to therapy.
  • Future preventative strategies may target the causative papillomavirus to reduce sarcoid incidence in horses.

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