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Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis
M Rivard1, P Malon, V Cerovský
1Laboratoires des Reactions Organiques Selectives, Université Paris-Sud, Orsay, France.
Amino Acids
|January 19, 1999
Abstract:
Papain-catalyzed regioselective cleavage of alpha-methyl ester in Z-DL-Asu(OMe)-OMe leads to Z-L-Asu(OMe)-OH and Z-D-Asu(OMe)-OMe. Subsequent saponifications yield Z-L-Asu-OH and Z-D-Asu-OH. The enzymatic alpha-ester hydrolysis was also achieved by subtilisin BPN' in organic solvent with low water content.