Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The anti-sigma factors

K T Hughes1, K Mathee

  • 1Department of Microbiology, University of Washington, Seattle 98195, USA. hughes@u.washington.edu

Annual Review of Microbiology
|January 19, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal assessment of nonavalent vaccine HPV types in a sample of sexually active African American women from ten U.S. Cities.

Vaccine·2021
Same author

Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2010
Same author

Detection of simple mutations and polymorphisms in large genomic regions.

Nucleic acids research·2001
Same author

Characterization of algG encoding C5-epimerase in the alginate biosynthetic gene cluster of Pseudomonas fluorescens.

Gene·2001
Same author

How and when are substrates selected for type III secretion?

Trends in microbiology·2001
Same author

A multipartite interaction between Salmonella transcription factor sigma28 and its anti-sigma factor FlgM: implications for sigma28 holoenzyme destabilization through stepwise binding.

Journal of molecular biology·2001
Same journal

Circadian Control of Host-Microbiome Symbioses.

Annual review of microbiology·2026
Same journal

Host-Pathogen Interactions in Malaria: Invasion, Neutralization, and Evasion.

Annual review of microbiology·2026
Same journal

From an Interest in Molecules to a Fascination with Microbes.

Annual review of microbiology·2026
Same journal

Bacterial Physiology in the Context of Algal Partners.

Annual review of microbiology·2026
Same journal

Introduction.

Annual review of microbiology·2025
Same journal

Decoding Microbial Community Assembly: Insights on Vectors of Infectious Diseases.

Annual review of microbiology·2025
See all related articles

Anti-sigma factors regulate gene transcription by inhibiting sigma transcription factors. A newly discovered class of inner-membrane-bound anti-sigma factors, the ECF subfamily, controls extracytoplasmic functions in bacteria.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Gene expression is tightly regulated at the transcriptional level.
  • Sigma transcription factors are key regulators of transcription initiation.
  • Anti-sigma factors antagonize sigma factors, modulating gene expression.

Purpose of the Study:

  • To review the known classes of anti-sigma factors.
  • To introduce the newly discovered ECF subfamily of anti-sigma factors.
  • To highlight the diverse cellular processes regulated by anti-sigma factors.

Main Methods:

  • Literature review of characterized anti-sigma factors.
  • Description of the newly identified ECF subfamily of anti-sigma factors.
  • Summary of the biological functions regulated by anti-sigma factors.

Related Experiment Videos

Main Results:

  • Cytoplasmic anti-sigma factors (e.g., AsiA, FlgM, SpoIIAB, RbsW, DnaK) are well-characterized and regulate various cellular processes.
  • A novel class of inner-membrane-bound anti-sigma factors, the ECF subfamily, has been identified in eubacteria.
  • ECF anti-sigma factors regulate extracytoplasmic functions.

Conclusions:

  • Anti-sigma factors represent a diverse group of gene expression regulators.
  • The discovery of ECF anti-sigma factors expands our understanding of transcriptional regulation.
  • These factors control a wide array of essential bacterial processes, including virulence and stress response.