[Effect of parenterally administered protein hydrolysates on the secretory function of the small intestine]

The effect of intravenous infusion of proteinic hydrolysates on the secretory function of the intestines was studied in dogs with an intestinal loop isolated starting from the initial portion of the jejunum. The preparation of proteinic hydrolysates, such as the caseine hydrolysate TSOLIPK, aminopeptide and hydrolysine L-103 with their drop-by-drop infusion into the posterior vena cava to dogs on an empty stomach were found to have in most cases an effect on the periodicity of the small intestine secretory activity. The infusion of proteinic hydrolyastes failed to exert any essential influence on the secretion of the dense proportion of the juice, whereas the secretion of the liquid component of the intestinal juice increased in all experiments involving introduction of all the proteinic hydrolysates. The concentration of the total protein in the liquid part of the intestinal juice with intravenous infusion of the preparations remained unchanged. At the same time, the amount of protein secreted together with the intestinal juice at the rate of single secretory action was in the instance of the caseine hydrolysate TSOLIPK and aminopeptide infusion proved 1 1/2--3 times as great as in the tests without infusion.