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Consistent reversible elevations of serum creatinine levels in severe hypothyroidism
1Rhode Island Hospital, Brown University School of Medicine, Providence, USA.
Archives of Internal Medicine
|January 19, 1999
Summary
Hypothyroidism consistently elevates serum creatinine levels, impacting renal function indicators. This effect is reversible, with some patients experiencing frankly abnormal creatinine values during the hypothyroid state.
Area of Science:
- Nephrology
- Endocrinology
- Clinical Chemistry
Background:
- Renal function indicators in hypothyroidism are not well-established.
- Limited discussion in standard medical texts.
Purpose of the Study:
- To characterize changes in serum creatinine during induced hypothyroidism.
- To assess the reversibility of these changes.
Main Methods:
- Evaluated 24 patients with iatrogenic hypothyroidism.
- Measured serum creatinine before, during, and after hypothyroidism.
Main Results:
- Serum creatinine was significantly higher in the hypothyroid state (89.7% of episodes).
- Mean creatinine increased from 76 to 103 µmol/L.
- Abnormal creatinine levels occurred in 6 of 36 hypothyroid episodes.
Conclusions:
- Hypothyroidism causes consistent and reversible serum creatinine elevation.
- Some individuals may develop abnormal creatinine levels.
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