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[Exertion-electrocardiographic and hemodynamic studies with oral verapamil in chronic ischemic heart disease]
Insights
Verapamil improved cardiac function and ECG in patients with chronic ischaemic heart disease during rest and exercise. This calcium channel blocker enhanced myocardial function without increasing tolerance or causing side effects.
Area of Science:
- Cardiology
- Pharmacology
- Clinical Medicine
Context:
- Investigated the long-term effects of Verapamil in patients with chronic ischaemic heart disease.
- Assessed impact on electrocardiogram (ECG), haemodynamic parameters, and systolic time intervals.
- Included patients undergoing both rest and exercise conditions.
Purpose:
- To evaluate the efficacy and safety of Verapamil in managing chronic ischaemic heart disease.
- To determine Verapamil's influence on cardiac function and haemodynamics.
- To assess Verapamil's effect on exercise-induced cardiac changes.
Summary:
- Verapamil (3 x 80 mg/day for 4 weeks) improved ST-T changes in ECG during rest and exercise.
- Myocardial function, assessed by LVET/ICT ratio, improved with Verapamil during exercise.
- Reduced double product and TTI observed, while pulmonary pressure remained unaffected.
Impact:
- Verapamil demonstrates potential as a therapeutic agent for chronic ischaemic heart disease.
- The study suggests Verapamil can improve cardiac performance and ECG parameters in affected patients.
- No adverse effects or increased tolerance were reported, indicating a favorable safety profile.
Abstract:
The effect of the Ca++ -antagonist Verapamil on the ECG, the haemodynamic parameters and the systolic time intervals was investigated in the long-term experiment on 12 patients with ascertained chronic ischaemic heart disease at reat and during exercise. The dosage was 3 x 80 mg/die during 4 weeks. The tolerance was not increased. The load-induced decrease of the ST-T-distance in the ECG was improved under load and in the recreation phase. The function of the myocardium, measured on the quotient LVET/ICT, improved under load with simultaneous decrease of the double product and the TTI, the pulmonary pressure, however, remained uninfluenced. Side-effects were not observed.