Good news for experimental concept but bad news for clinically effective therapy

Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs.

Journal of molecular and cellular cardiology·2001

Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.

Journal of molecular and cellular cardiology·2001

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion.

American heart journal·1999

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Circulation·1998

Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.

Journal of the American College of Cardiology·1998

Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

Circulation·1998

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Circulation·2026

Pathology of Genetic Variants in Spontaneous Coronary Artery Dissection.

Circulation·2026

PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

Circulation·2026

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest.

Circulation·2026

Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association.

Circulation·2026

Inhibition of Programmed Cell Death-1 in Cytotoxic CD8+ T Cells Exacerbates Pressure Overload-Induced Cardiac Injury.

Circulation·2026

EGFR kinase inhibitors from novel thiazole derivatives: synthesis, anticolon cancer, docking, and ADME studies.

Future medicinal chemistry·2026

Beyond the ceiling: A critical analysis of microRNA research in cutaneous T-cell lymphoma and a roadmap forward.

The Journal of investigative dermatology·2026

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

Cancer discovery·2026

Epigenetic Repression of Type I Interferon Signaling by RUNX2 Drives Immune Checkpoint Blockade Resistance in Osteosarcoma.

Cancer research·2026

The Trispecific Antibody IBI3019 Integrates CDH17-Enhanced EGFR Antagonism with Optimized CD16A Engagement to Elicit Potent Antitumor Activity with Minimal Toxicity.

Cancer research·2026

Targeting glutaminase (GLS) to suppress CXCL8 secretion and sensitize esophageal squamous cell carcinoma to immunotherapy.

Journal of chemotherapy (Florence, Italy)·2026

Related Experiment Videos

Good news for experimental concept but bad news for clinically effective therapy

Related Concept Videos

Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs.

Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion.

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.

Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Pathology of Genetic Variants in Spontaneous Coronary Artery Dissection.

PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest.

Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association.

Inhibition of Programmed Cell Death-1 in Cytotoxic CD8+ T Cells Exacerbates Pressure Overload-Induced Cardiac Injury.

EGFR kinase inhibitors from novel thiazole derivatives: synthesis, anticolon cancer, docking, and ADME studies.

Beyond the ceiling: A critical analysis of microRNA research in cutaneous T-cell lymphoma and a roadmap forward.

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

Epigenetic Repression of Type I Interferon Signaling by RUNX2 Drives Immune Checkpoint Blockade Resistance in Osteosarcoma.

The Trispecific Antibody IBI3019 Integrates CDH17-Enhanced EGFR Antagonism with Optimized CD16A Engagement to Elicit Potent Antitumor Activity with Minimal Toxicity.

Targeting glutaminase (GLS) to suppress CXCL8 secretion and sensitize esophageal squamous cell carcinoma to immunotherapy.

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Good news for experimental concept but bad news for clinically effective therapy

Related Concept Videos

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