Good news for experimental concept but bad news for clinically effective therapy

Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs.

Journal of molecular and cellular cardiology·2001

Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.

Journal of molecular and cellular cardiology·2001

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion.

American heart journal·1999

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Circulation·1998

Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.

Journal of the American College of Cardiology·1998

Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

Circulation·1998

Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association.

Circulation·2026

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Circulation·2026

Pathology of Genetic Variants in Spontaneous Coronary Artery Dissection.

Circulation·2026

PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

Circulation·2026

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest.

Circulation·2026

Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association.

Circulation·2026

Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation.

Cancer science·2026

FIN56-induced ferroptosis suppresses the development of endometriosis by augmenting mitochondrial ROS and lipid peroxidation via the ACACA/ARID5A/NOX4 axis.

Chinese medical journal·2026

Regulatory and Quality Considerations of Antibody-drug Conjugates.

AAPS PharmSciTech·2026

HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.

Nature communications·2026

Dual HBV cccDNA-linked HiBiT reporter hepatocyte models for screening of candidate cccDNA modulators.

Virulence·2026

Related Experiment Videos

Good news for experimental concept but bad news for clinically effective therapy

Related Concept Videos

Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs.

Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion.

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.

Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association.

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Pathology of Genetic Variants in Spontaneous Coronary Artery Dissection.

PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest.

Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association.

Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation.

FIN56-induced ferroptosis suppresses the development of endometriosis by augmenting mitochondrial ROS and lipid peroxidation via the ACACA/ARID5A/NOX4 axis.

Regulatory and Quality Considerations of Antibody-drug Conjugates.

HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.

Dual HBV cccDNA-linked HiBiT reporter hepatocyte models for screening of candidate cccDNA modulators.

Related Experiment Videos

Good news for experimental concept but bad news for clinically effective therapy

Related Concept Videos

Related Articles