Good news for experimental concept but bad news for clinically effective therapy

Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs.

Journal of molecular and cellular cardiology·2001

Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.

Journal of molecular and cellular cardiology·2001

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion.

American heart journal·1999

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Circulation·1998

Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.

Journal of the American College of Cardiology·1998

Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

Circulation·1998

Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association.

Circulation·2026

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Circulation·2026

Pathology of Genetic Variants in Spontaneous Coronary Artery Dissection.

Circulation·2026

PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

Circulation·2026

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest.

Circulation·2026

Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association.

Circulation·2026

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment.

The Journal of experimental medicine·2026

Activation of PP2A-B56a leads to aberrant EGFR signaling and proliferative phenotypes in PDAC.

Molecular cancer therapeutics·2026

Toward Fit-for-Purpose Data for Drug Assessment in Non-small Cell Lung Cancer: A Core Dataset.

Clinical pharmacology and therapeutics·2026

Regulation of the lncRNA NEAT1 by p53-ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC.

Molecular oncology·2026

Payload-Free [89Zr]Zr-DFO*-sq-Enfortumab ImmunoPET for Imaging Nectin-4 Expression in Bladder Cancer.

Molecular pharmaceutics·2026

Preclinical Evaluation of [68Ga]Ga-CS03 as a Novel GPC3-Targeted Probe for Imaging GPC3 in Hepatocellular Carcinoma Models.

Molecular pharmaceutics·2026

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Good news for experimental concept but bad news for clinically effective therapy

Related Concept Videos

Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs.

Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection.

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb. Global Utilization of Strategies for Total Occlusion.

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.

Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.

Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association.

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Pathology of Genetic Variants in Spontaneous Coronary Artery Dissection.

PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

Correlation Between EMS Agency Rates of Survival to Hospital Admission and Hospital Survival Outcomes for Cardiac Arrest.

Important Residual Lesions and Early Unplanned Reinterventions After Pediatric Cardiac Surgery: A Scientific Statement From the American Heart Association.

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment.

Activation of PP2A-B56a leads to aberrant EGFR signaling and proliferative phenotypes in PDAC.

Toward Fit-for-Purpose Data for Drug Assessment in Non-small Cell Lung Cancer: A Core Dataset.

Regulation of the lncRNA NEAT1 by p53-ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC.

Payload-Free [89Zr]Zr-DFO*-sq-Enfortumab ImmunoPET for Imaging Nectin-4 Expression in Bladder Cancer.

Preclinical Evaluation of [68Ga]Ga-CS03 as a Novel GPC3-Targeted Probe for Imaging GPC3 in Hepatocellular Carcinoma Models.

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Good news for experimental concept but bad news for clinically effective therapy

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