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Benign cutaneous Degos' disease

A M Farrell1, J Moss, C Costello

  • 1Department of Histopathology, Charing Cross and Westminster Medical School, London, U.K.

The British Journal of Dermatology
|January 20, 1999
PubMed
Summary
This summary is machine-generated.

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A woman with Degos disease and lupus anticoagulant showed tubular structures in endothelial cells. Aspirin therapy halted her skin lesions, with no organ involvement after four years.

Area of Science:

  • Vascular Biology
  • Dermatology
  • Immunology

Background:

  • Degos disease is a rare condition characterized by skin lesions.
  • Lupus anticoagulant is an autoimmune antibody associated with thrombotic events.

Observation:

  • A 44-year-old woman presented with Degos disease and a lupus anticoagulant.
  • Electron microscopy revealed interwoven tubular structures within endothelial cells of mature lesions.
  • The patient developed cutaneous lesions without systemic organ involvement over four years.

Findings:

  • The observed endothelial cell changes are consistent with previous Degos disease findings.
  • Aspirin treatment (300 mg daily) effectively arrested the progression of cutaneous lesions.
  • The patient showed no evidence of internal organ involvement during the four-year follow-up.

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Implications:

  • This case highlights the potential link between lupus anticoagulant and Degos disease.
  • Low-dose aspirin may be a viable treatment option for managing cutaneous Degos disease.
  • Further research is needed to elucidate the pathogenesis of Degos disease and its association with autoimmune conditions.