Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA vaccines: vector design, delivery, and antigen presentation

D M Feltquate1

  • 1Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA. david.feltquate@ummed.edu

Journal of Cellular Biochemistry. Supplement
|January 20, 1999
PubMed
Summary

DNA vaccines utilize antigen-expressing plasmid DNA for protective immunity. This review covers advancements in vaccine vectors, delivery, cellular transfection, and antigen presentation, while noting remaining questions in immune response development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2010
Same author

Effect of CpG methylation on isotype and magnitude of antibody responses to influenza hemagglutinin-expressing plasmid.

DNA and cell biology·1999
Same author

DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs.

The Journal of infectious diseases·1997
Same author

Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization.

Journal of immunology (Baltimore, Md. : 1950)·1997
Same author

DNA vaccines.

AIDS research and human retroviruses·1996
Same author

Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone beta-subunit gene.

American journal of human genetics·1990

Area of Science:

  • Immunology
  • Molecular Biology
  • Vaccinology

Background:

  • DNA vaccines, using antigen-expressing plasmid DNA, aim to elicit protective immune responses.
  • Significant progress has been achieved in DNA vaccine vector design and delivery systems over the past five years.
  • Key challenges persist concerning the mechanisms of cellular transfection and the subsequent development of immune responses.

Purpose of the Study:

  • To review the functional aspects of DNA vaccines.
  • To discuss advancements in DNA vaccine vector design and delivery methods.
  • To explore cellular transfection mechanisms and antigen presentation in the context of DNA vaccination.

Main Methods:

  • Literature review of studies on DNA vaccine technology.
  • Analysis of research on vaccine vector design and delivery systems.

Related Experiment Videos

  • Examination of data concerning cellular transfection and antigen presentation pathways.

    • Main Results:

    • DNA vaccine technology has seen major strides in vector design and delivery.
    • Understanding of cellular transfection and immune response development remains incomplete.
    • Antigen presentation is a critical factor influenced by vector design and delivery.

    Conclusions:

    • DNA vaccines represent a promising approach to inducing protective immunity.
    • Further research is needed to fully elucidate cellular transfection and immune response mechanisms.
    • Optimized vector design and delivery are crucial for enhancing DNA vaccine efficacy.