Related Experiment Video
Updated: Aug 2, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
An infant with Costello syndrome complicated with fatal hypertrophic obstructive cardiomyopathy
1Department of Pediatrics, Sapporo Medical University School of Medicine, Japan. tomitah@sapmed.ac.jp
Abstract:
We report a 3-month-old girl with Costello syndrome complicating fatal hypertrophic obstructive cardiomyopathy. She had typical findings of this syndrome, slight dyspnea and persistent wheezing. Doppler echocardiography revealed asymmetric septal hypertrophy and systolic anterior movement of the anterior mitral leaflet. There was grade 1 mitral regurgitation. Although once her heart failure had been controlled medically, she died suddenly following deterioration of her heart condition. Costello syndrome can complicate fatal hypertrophic obstructive cardiomyopathy.
Related Concept Videos
Mitral Stenosis I: Introduction
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy II: Dilated Cardiomyopathy
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
Cardiomyopathy V: Interprofessional Care

