[Possible therapeutic influences on experimentally induced edemas (author's transl)]

In pathogenetically different models the antiedemic effect of extractum hippocastani semen (EHS) for intravenous and oral use was to be demonstrated. The histamine-induced edema of the skin, the postischemic edema of muscle and the cerebral edema provoked by cold injury were used. In all the models tested, it was possible to obtain reproducible numerical results which made statistical evaluation of the experiments possible. Antiedemic protective effects could be demonstrated in all investigations, whereas in one model a curative effect could be proved, too.