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[Type 2 diabetes: new therapeutic perspectives]

B Bouhanick1, G Berrut, P Fressinaud

  • 1Service de Médecine B, Centre Hospitalier et Universitaire d'Angers. BeBouhanick@chu-angers.fr

Presse Medicale (Paris, France : 1983)
|January 20, 1999
PubMed
Summary

The United Kingdom Prospective Diabetes Study (UKPDS) found that better blood glucose control in type 2 diabetes patients reduces complications, particularly microangiopathy. However, it did not lower diabetes-related deaths or heart attack risk.

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Area of Science:

  • Endocrinology
  • Clinical Trials
  • Public Health

Background:

  • The United Kingdom Prospective Diabetes Study (UKPDS) investigated the long-term effects of blood glucose control in type 2 diabetes.
  • Type 2 diabetes mellitus affects millions globally, necessitating research into effective management strategies.

Purpose of the Study:

  • To determine if improved blood glucose control prevents diabetes complications.
  • To assess the impact of glycemic control on morbidity and mortality in type 2 diabetes patients.

Main Methods:

  • Multi-center, prospective, randomized intervention trial.
  • Involved 5102 newly-diagnosed patients with type 2 diabetes mellitus.
  • Focused on the effects of improved blood glucose management.

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Main Results:

  • Improved blood glucose control significantly reduced diabetes complications, primarily microangiopathy.
  • No significant reduction was observed in diabetes-related deaths.
  • The risk of myocardial infarction or sudden death was not reduced by improved glycemic control.

Conclusions:

  • Intensified blood glucose control is beneficial for reducing microvascular complications in type 2 diabetes.
  • While improving glycemic control impacts certain complications, it does not appear to affect overall mortality or major cardiovascular events like heart attacks.