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[Prophylactic nefopam administration for post-anesthetic shivering]

S N Piper1, C C Schmidt, S W Suttner

  • 1Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Ludwigshafen.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|January 20, 1999
PubMed
Summary

Nefopam effectively prevents post-anesthetic shivering, a common complication. This study found nefopam significantly reduced shivering incidence without prolonging patient awakening or negatively impacting hemodynamics.

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Post-anesthetic shivering is a frequent complication, particularly in patients with cardiovascular or pulmonary conditions.
  • The exact cause of post-anesthetic shivering remains unknown.
  • Effective prophylactic strategies are needed to mitigate this complication.

Purpose of the Study:

  • To evaluate the efficacy of nefopam in preventing post-anesthetic shivering.
  • To assess the impact of nefopam on hemodynamic parameters.
  • To determine if nefopam influences the time to extubation.

Main Methods:

  • A double-blind, randomized study involving 30 patients (ASA I-II).
  • Patients received either nefopam (0.15 mg/kg) or placebo after isoflurane anesthesia.
  • Key parameters monitored included heart rate, mean arterial blood pressure, temperature, O2-saturation, and shivering severity.

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Main Results:

  • Nefopam significantly reduced shivering incidence (6.6% vs. 60% in placebo group, p < 0.05).
  • Nefopam administration led to a significant decrease in heart rate postoperatively.
  • No prolonged awakening was observed in the nefopam group; MAP and O2-saturation remained similar between groups.

Conclusions:

  • Prophylactic administration of nefopam is effective in suppressing post-anesthetic shivering.
  • Nefopam does not appear to prolong awakening time after anesthesia.
  • Nefopam demonstrates potential as a safe and effective agent for shivering prophylaxis.