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1Department of Pathology, Carolinas Medical Center, Charlotte, North Carolina 28232-2861, USA.
Steady advances in our scientific understanding of primary extranodal mucosa-associated lymphoid tissue-type lymphomas have been achieved during the past 14 years, leading to their inclusion within the International Lymphoma Study Group (revised European-American classification of lymphoid neoplasms, known as REAL) classification as extranodal B-marginal zone lymphomas. Although most cases conform to prototype criteria, exceptional cases, such as those discussed at the Fourth Slide Workshop of the Society for Hematopathology on Extranodal Hematopoietic/Lymphoid Disorders, September 11-13, 1997, raise issues relating to microscopic, immunophenotypic, and clinical behavioral limits for diagnostic criteria. Furthermore, questions about therapeutic management have only begun to be addressed.
Steady advances in our scientific understanding of primary extranodal mucosa-associated lymphoid tissue-type lymphomas have been achieved during the past 14 years, leading to their inclusion within the International Lymphoma Study Group (revised European-American classification of lymphoid neoplasms, known as REAL) classification as extranodal B-marginal zone lymphomas. Although most cases conform to prototype criteria, exceptional cases, such as those discussed at the Fourth Slide Workshop of the Society for Hematopathology on Extranodal Hematopoietic/Lymphoid Disorders, September 11-13, 1997, raise issues relating to microscopic, immunophenotypic, and clinical behavioral limits for diagnostic criteria. Furthermore, questions about therapeutic management have only begun to be addressed.
