Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function

A F Arnsten1, R Mathew, R Ubriani

  • 1Section of Neurobiology, Yale Medical School, New Haven, Connecticut 06520-8001, USA.

Biological Psychiatry
|January 23, 1999
PubMed
Summary

Stimulating alpha-1 adrenoceptors in the prefrontal cortex (PFC) impairs spatial working memory in rats. This effect is reversed by antagonists, suggesting alpha-1 receptors influence cognitive function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermal stability of multi-tier layer hen housing with all-year sidewall inlet ventilation system.

Poultry science·2025
Same author

Prenatal light exposure affects diurnal rhythms and visual development of the layer embryonic retina.

Poultry science·2024
Same author

Spatial distribution, movement, body damage, and feather condition of laying hens in a multi-tier system.

Poultry science·2023
Same author

Effects of different light-emitting diode light on hatch performance, embryo development, eye structure, and plasma melatonin in layer incubation.

Poultry science·2023
Same author

[Endovascular stenting for idiopathic intracranial hypertension with different types of venous sinus stenosis].

Zhonghua nei ke za zhi·2021
Same author

[Chaperone-mediated tubulinopathy caused by TBCD gene complex heterozygous variation in a child].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2020

Area of Science:

  • Neuroscience
  • Adrenergic Signaling
  • Cognitive Function

Background:

  • Neuropsychiatric disorders often involve high noradrenergic activity.
  • Antipsychotic drugs frequently block alpha-1 adrenoceptors.
  • The role of alpha-1 adrenoceptors in higher cortical functions remains unclear.

Purpose of the Study:

  • To investigate the impact of alpha-1 adrenoceptor stimulation in the prefrontal cortex (PFC) on cognitive performance.
  • To determine if alpha-1 adrenoceptor actions in the PFC are mediated by the phosphotidylinositol (PI) pathway.

Main Methods:

  • Administered the alpha-1 agonist phenylephrine into the rat PFC during a spatial working memory task (delayed alternation).
  • Challenged the effects of phenylephrine with the alpha-1 antagonist uripidil or lithium chloride, which inhibits PI turnover.

Related Experiment Videos

Main Results:

  • Phenylephrine infusion significantly worsened delayed alternation performance.
  • Both uripidil coinfusion and lithium pretreatment reversed the cognitive impairment caused by phenylephrine.
  • Results support the involvement of alpha-1 adrenoceptors linked to the PI pathway.

Conclusions:

  • Alpha-1 adrenoceptor activation in the PFC impairs cognitive function.
  • Overstimulation of these receptors may underlie PFC deficits seen in conditions like mania and anxiety.
  • Findings highlight the role of alpha-1 adrenoceptors in cognitive processes and neuropsychiatric disorders.