Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Post-transplantation lymphomas and Epstein-Barr virus]

S Caillard1, F Heibel, M Benaicha

  • 1Service de néphrologie, Hôpitaux universitaires de Strasbourg.

Nephrologie
|January 23, 1999
PubMed
Summary

Post-transplant lymphoproliferative disorders (PTLD) are a serious complication after organ transplants, particularly kidney transplants. Early detection and antiviral treatment for Epstein-Barr virus (EBV) are crucial for managing these lymphoid abnormalities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokine release syndrome-associated encephalopathy in patients with COVID-19.

European journal of neurology·2020
Same author

Global Transplantation COVID Report March 2020.

Transplantation·2020
Same author

Torquetenovirus viremia for early prediction of graft rejection after kidney transplantation.

The Journal of infection·2019
Same author

Type 1 primary hyperoxaluria: A case report and focus on bone impairment of systemic oxalosis.

Morphologie : bulletin de l'Association des anatomistes·2017
Same author

Modified technique used for sagittal splitting of the mandible.

Journal of stomatology, oral and maxillofacial surgery·2017
Same author

Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

Area of Science:

  • Immunology
  • Virology
  • Oncology

Context:

  • Post-transplant lymphoproliferative disorders (PTLD) are a significant complication following organ transplantation.
  • The incidence of PTLD varies based on the transplanted organ and immunosuppressive therapy, with kidney transplants showing an estimated 1-2% incidence.
  • PTLD encompasses a heterogeneous group of lymphoid proliferations with diverse clinical and morphological presentations.

Purpose:

  • To highlight the association between Epstein-Barr virus (EBV) and PTLD.
  • To discuss the spectrum of PTLD manifestations, from infectious mononucleosis-like syndromes to polyclonal or monoclonal lymphoproliferations.
  • To emphasize the need for early detection, monitoring, and potential prophylactic antiviral strategies for EBV-associated lymphoid abnormalities.

Summary:

Related Experiment Videos

  • PTLD is a severe complication of organ transplantation, closely linked to Epstein-Barr virus (EBV).
  • Manifestations range from mild syndromes to aggressive lymphoproliferations requiring complex treatment.
  • The oncogenic mechanisms of EBV, including viral gene expression and cytokine involvement, are under investigation.

Impact:

  • Early detection and monitoring of EBV-induced lymphoid abnormalities are essential for timely and effective antiviral treatment.
  • Prophylactic antiviral therapy should be considered to mitigate the risk of PTLD development.
  • Understanding EBV's role in PTLD can lead to improved patient outcomes and management strategies in transplantation.