Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Small-diameter vascular graft prostheses: current status

G W Bos1, A A Poot, T Beugeling

  • 1Fac. Chemical Technology, Sect. Polymer Chemistry and Biomaterials, and Inst. Biomedical Technology, Univ. Twente, Enschede, The Netherlands.

Archives of Physiology and Biochemistry
|January 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tensile properties of segmented block copolymers with monodisperse hard segments.

Journal of materials science·2021
Same author

Delivery systems for the treatment of degenerated intervertebral discs.

Advanced drug delivery reviews·2014
Same author

Corrugated round fibers to improve cell adhesion and proliferation in tissue engineering scaffolds.

Acta biomaterialia·2013
Same author

Structure formation and hydrogen bonding in all-aliphatic segmented copolymers with uniform hard segments.

Acta biomaterialia·2012
Same author

Flexible, elastic and tear-resistant networks prepared by photo-crosslinking poly(trimethylene carbonate) macromers.

Acta biomaterialia·2012
Same author

High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo.

European cells & materials·2012
Same journal

AMPK phosphorylation regulates HIIT to improve the molecular mechanism of exercise metabolic syndrome: MG53 protein molecular mechanism and exercise nutrition intervention.

Archives of physiology and biochemistry·2026
Same journal

Correction.

Archives of physiology and biochemistry·2026
Same journal

Protein cotargeting of mechanotransduction pathways improves functional orthopedic repair while enhancing anesthetic physiological stability.

Archives of physiology and biochemistry·2026
Same journal

Protective effect of quercetin on ulcerative colitis via p38 MAPK-MK2/MK3 signalling pathway: mechanism of anti-inflammatory cellular action.

Archives of physiology and biochemistry·2026
Same journal

The therapeutic effect of phytochemicals on aflatoxin B1-induced intestinal injury: the roles of oxidative stress and inflammation.

Archives of physiology and biochemistry·2026
Same journal

The role of SOST protein (osteocalcin) regulatory mechanism in enhancing bone strength during endurance training: Wnt/β-catenin pathway.

Archives of physiology and biochemistry·2026
See all related articles

Small-diameter vascular grafts made of Dacron and Teflon often fail. Tissue engineering offers promising solutions for improving artificial vascular graft patency and long-term success.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Large-diameter vascular grafts (>5 mm) demonstrate excellent long-term patency (>10 years).
  • Small-diameter vascular grafts (e.g., Dacron, Teflon) frequently occlude rapidly after implantation, limiting their clinical utility.
  • There is a critical need for durable small-diameter artificial vascular grafts.

Purpose of the Study:

  • To review strategies for enhancing the patency of small-diameter vascular grafts.
  • To assess the current status of small-diameter vascular grafts in clinical trials.
  • To explore future perspectives in artificial vascular graft development.

Main Methods:

  • Literature review of existing strategies for small-diameter vascular graft improvement.

Related Experiment Videos

  • Analysis of current clinical trial data for artificial vascular grafts.
  • Discussion of emerging tissue engineering approaches for vascular prostheses.

    • Main Results:

    • Current synthetic small-diameter grafts (Dacron, Teflon) exhibit poor patency rates due to rapid occlusion.
    • Various strategies are being investigated to improve graft performance, including surface modifications and biomimetic designs.
    • Tissue engineering approaches show significant potential for creating functional small-diameter vascular grafts.

    Conclusions:

    • The development of effective small-diameter vascular prostheses remains a significant challenge in vascular surgery.
    • Recent advancements in tissue engineering offer a promising future for improving the patency and longevity of artificial vascular grafts.
    • Continued research and clinical evaluation are essential for realizing the full potential of next-generation vascular grafts.