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Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury
G S Scott1, L B Jakeman, B T Stokes
1Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Annals of Neurology
|January 23, 1999
Abstract:
Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.