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Related Experiment Videos

Diclofenac does not decrease renal blood flow or glomerular filtration in elderly patients undergoing orthopedic

B Fredman1, E Zohar, E Golan

  • 1Department of Anesthesiology and Intensive Care, Meir Hospital, Kfar Saba, Israel.

Anesthesia and Analgesia
|January 23, 1999
PubMed
Summary
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Nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac do not harm kidney function in elderly surgical patients. This study found no adverse effects on renal blood flow or filtration rates when NSAIDs were used perioperatively.

Area of Science:

  • Anesthesiology
  • Nephrology
  • Geriatric Medicine

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular for perioperative pain but raise concerns regarding renal function in geriatric patients.
  • Previous research has not assessed the perioperative impact of NSAIDs on renal blood flow (RBF) and glomerular filtration rate (GFR) in this population.

Purpose of the Study:

  • To evaluate the effect of diclofenac, a common NSAID, on RBF and GFR in elderly patients undergoing femur surgery.
  • To determine if NSAID administration during the perioperative period adversely affects renal function in geriatric surgical patients.

Main Methods:

  • A prospective, controlled, double-blinded study involving 20 geriatric patients (>65 yr) undergoing femur surgery.
  • Patients received either diclofenac or saline infusion during anesthesia and surgery.

Related Experiment Videos

  • Renal blood flow (assessed by effective renal plasma flow - ERPF) and GFR were measured using inulin and paraaminohippurate clearance at multiple time points.

    • Main Results:

    • Both ERPF and GFR showed significant decreases compared to baseline values after anesthesia induction and throughout the surgical period.
    • No significant differences in ERPF or GFR were observed between the diclofenac group and the saline group.
    • These findings indicate that diclofenac did not exacerbate the expected perioperative decline in renal function.

    Conclusions:

    • Intraoperative administration of diclofenac does not negatively impact glomerular filtration rate or effective renal plasma flow in normovolemic geriatric patients.
    • Diclofenac can be safely administered during the perioperative period for pain management in this patient group.