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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...

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Related Experiment Video

Updated: Jun 25, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 20, 2010

Diversion colitis: a trigger for ulcerative colitis in the in-stream colon?

A G Lim1, F L Langmead, R M Feakins

  • 1Department of Gastroenterology, Royal London Hospital, Whitechapel, London, UK.

Gut
|January 23, 1999
PubMed
Summary

Diversion colitis, an inflammation in the defunctioned colon, may trigger ulcerative colitis in susceptible individuals. This suggests discontinuous large intestine inflammation could be a risk factor for developing ulcerative colitis.

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Inflammatory Bowel Disease Research

Background:

  • The precise cause of ulcerative colitis remains unknown.
  • Inflammatory bowel disease (IBD) research is ongoing.
  • Understanding ulcerative colitis aetiology is crucial for effective treatment.

Observation:

  • Two patients without prior IBD developed ulcerative colitis.
  • Diversion colitis occurred in the defunctioned rectosigmoid colon after end colostomy for fecal incontinence.
  • Colitis resembling ulcerative colitis developed in the in-stream colon proximal to the colostomy approximately one year later.

Findings:

  • These cases indicate that diversion colitis might be a risk factor for ulcerative colitis in predisposed individuals.
  • Ulcerative colitis can potentially be triggered by inflammation in a separate part of the large intestine.
  • Anatomically discontinuous inflammation may play a role in ulcerative colitis pathogenesis.

Implications:

  • This study suggests a novel potential risk factor for ulcerative colitis development.
  • Further research into the link between diversion colitis and ulcerative colitis is warranted.
  • Findings may inform preventative strategies or early detection in at-risk populations.