Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pure red cell aplasia

B S Skikne, S R Lynch, W R Bezwoda

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 14, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mechanism of thrombocytopenia in chronic hepatitis C as evaluated by the immature platelet fraction.

    International journal of laboratory hematology·2012
    Same author

    Iron deficiency and the measurement of iron status.

    Nutrition research reviews·2008
    Same author

    Giant anal condylomatosis after allogeneic bone marrow transplantation: a rare complication of human papilloma virus infection.

    Transplant infectious disease : an official journal of the Transplantation Society·2007
    Same author

    Fatal chemotherapy-induced encephalopathy following high-dose therapy for metastatic breast cancer: a case report and review of the literature.

    Bone marrow transplantation·2003
    Same author

    Effects of erythropoietin therapy on iron absorption in chronic renal failure.

    The Journal of laboratory and clinical medicine·2000
    Same author

    Reversible methotrexate associated lymphoproliferative disease evolving into Hodgkin's disease.

    The Journal of rheumatology·2000

    Pure red cell aplasia (PRCA) can present with various associated conditions, including thymoma and lymphoma. Autoimmune factors likely contribute to PRCA development, as evidenced by co-existing autoimmune disturbances in most patients.

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Pure red cell aplasia (PRCA) is a rare disorder characterized by the selective suppression of erythropoiesis.
    • Understanding the underlying causes and associations of PRCA is crucial for effective management.

    Observation:

    • This study describes the clinical presentation and course of 5 patients with PRCA.
    • Associated conditions included thymoma in one patient and lymphocytic lymphoma in another.
    • Pregnancy triggered PRCA recurrence in two patients.

    Findings:

    • Three patients had PRCA without concomitant diseases.
    • Four out of five PRCA patients showed evidence of other autoimmune disturbances.
    • These findings support an autoimmune basis for pure red cell aplasia.

    Related Experiment Videos

    Implications:

    • PRCA may have an autoimmune etiology, suggesting potential immunomodulatory treatment strategies.
    • Recognition of associated conditions like thymoma and lymphoma is important for comprehensive patient care.
    • The influence of pregnancy on PRCA recurrence highlights the need for careful monitoring in affected women.