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The primary empty sella an endocrine study on 12 cases

G Schaison, J Metzger

    Acta Endocrinologica
    |November 1, 1976
    PubMed
    Summary
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    Primary empty sella turcica is a structural condition with no direct endocrine impact. While some patients exhibit pituitary disorders, these are often incidental or unrelated to the empty sella itself.

    Area of Science:

    • Neuroendocrinology
    • Radiology

    Background:

    • Primary empty sella turcica is a condition where the pituitary gland appears flattened within the sella turcica.
    • The endocrine implications of this anatomical variation require further investigation.

    Purpose of the Study:

    • To investigate the endocrine function in patients with primary empty sella turcica.
    • To determine if there is a causal relationship between empty sella and pituitary dysfunction.

    Main Methods:

    • Studied 12 patients with primary empty sella turcica.
    • Performed comprehensive endocrine function tests including growth hormone (GH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotropin (TSH), prolactin, and adrenocorticotropin (ACTH) reserve tests.

    Main Results:

    Related Experiment Videos

    • Five patients (group A) showed no endocrine disturbances.
    • Seven patients (group B) had hypothalamo-pituitary disorders, including panhypopituitarism and amenorrhea-galactorrhea syndromes, some linked to adenomas or other causes.
    • No direct causal relationship was found between the empty sella and pituitary disturbances.

    Conclusions:

    • Primary empty sella turcica is primarily a neuroanatomical and neuroradiological finding.
    • Endocrine implications are not inherent to the condition, with associated pituitary disorders often being incidental or due to other pathologies like microadenomas.