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Related Experiment Videos

Acid-base regulation in pregnancy

V S Lim, A I Katz, M D Lindheimer

    The American Journal of Physiology
    |December 1, 1976
    PubMed
    Summary

    During pregnancy, plasma bicarbonate decreases. This study in 3rd-trimester women found renal bicarbonate reabsorption is nearly complete, suggesting normal kidney function maintains this change.

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    Area of Science:

    • Obstetrics and Gynecology
    • Renal Physiology
    • Acid-Base Metabolism

    Background:

    • Plasma bicarbonate levels naturally decrease during pregnancy.
    • The physiological mechanisms maintaining this decrement are not fully understood.
    • Potential roles of extracellular volume expansion and parathyroid hormone (iPTH) require investigation.

    Purpose of the Study:

    • To evaluate acid-base metabolism in pregnant women.
    • To assess the renal handling of bicarbonate during gestation.
    • To investigate the influence of dietary sodium on acid-base balance in pregnancy.

    Main Methods:

    • Studied eleven 3rd-trimester pregnant women.
    • Administered slow infusion of hypertonic sodium bicarbonate (NaHCO3).
    • Conducted metabolic balance studies comparing high- and low-sodium diets.

    Main Results:

    • Baseline pH and PCO2 were 7.44 and 27.3 mmHg, respectively.
    • Renal bicarbonate reclamation was nearly complete, with no evidence of splay or tubular maximum.
    • Urine acidification and distal hydrogen ion secretory ability were normal.
    • Blood pH and plasma bicarbonate increased significantly when switching from a high- to a low-sodium diet.

    Conclusions:

    • Renal mechanisms effectively conserve bicarbonate during pregnancy.
    • Normal kidney function appears to maintain the decreased plasma bicarbonate levels.
    • Dietary sodium intake influences acid-base balance in pregnant individuals.

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