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Studies on microfibrils from alpha-keratin

L N Jones

    Biochimica Et Biophysica Acta
    |October 28, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Researchers isolated and purified alpha-keratin microfibrils from developing hair follicles. These microfibrils, crucial for hair structure, were studied directly to understand their physical and chemical properties.

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    Area of Science:

    • Biochemistry
    • Cell Biology
    • Materials Science

    Background:

    • Mammalian hair is primarily composed of alpha-keratin.
    • Understanding the structure of keratin at the microfibril level is key to hair science.

    Purpose of the Study:

    • To isolate and purify alpha-keratin microfibrils from developing mammalian hair follicles.
    • To characterize the physical and chemical properties of these microfibrils.

    Main Methods:

    • Isolation of alpha-keratin microfibrils from presumptive hair follicle cortex.
    • Purification using centrifugation.
    • Analysis of amino acid and protein composition.
    • High-resolution electron microscopy.

    Main Results:

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    • Successfully isolated alpha-keratin microfibrils in sufficient quantities for direct study.
    • The composition of isolated microfibrils matched the low-sulphur protein fraction of keratinized hair.
    • Electron microscopy revealed structural features consistent with previous observations in sectioned hair.

    Conclusions:

    • The study provides direct physical and chemical characterization of alpha-keratin microfibrils.
    • These findings support the role of these microfibrils as fundamental structural components of mammalian hair.