[Renin-angiotensin system in the presence of altered prostaglandin synthesis]

The activity of the renin-angiotensin system was studied in experiments on rats under conditions of the inhibited prostaglandin synthesis. It was found that the injection of indometacin in non-hypertensive doses was accompanied by a substantial lowering of the plasma renin activity and of the secretory function of the juxtaglomerular apparatus of the kidneys. The amount of lipid granules increased in the interstitial cells simultaneously, this reflecting the inhibition of prostaglandin synthesis in the medulla of the kidneys. The results of these experiments permit the assumption to be made that the renin synthesis in the juxtaglomerular apparatus was connected with the synthesis of renal prostaglanins.