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[Relationship between the development of experimental leukemia and animals' capacity for a humoral immune response]
The tests on AKR and C57BL mice of different age were conducted using experimental models of transplanted Gross leukemia (the first passage), Pujman leukemia and spontaneous AKR mouse leukemia. An inverse relationship between the ability of mice to produce humoral antibodies and their susceptibility to transplantation of singeneic leukemic cells and the incidence of spontaneous leukemia has been established. The differences in the ability of the animals to develop immune response to a heterologous antigen were connected with the physiological processes of the aging organism. The data obtained indicated that the failure of one of the links of immunity did not always result in a higher risk of tumor development.
The tests on AKR and C57BL mice of different age were conducted using experimental models of transplanted Gross leukemia (the first passage), Pujman leukemia and spontaneous AKR mouse leukemia. An inverse relationship between the ability of mice to produce humoral antibodies and their susceptibility to transplantation of singeneic leukemic cells and the incidence of spontaneous leukemia has been established. The differences in the ability of the animals to develop immune response to a heterologous antigen were connected with the physiological processes of the aging organism. The data obtained indicated that the failure of one of the links of immunity did not always result in a higher risk of tumor development.