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[Brain development: genetic and exogenous factors]

N Herschkowitz, E Rossi

    Bulletin Der Schweizerischen Akademie Der Medizinischen Wissenschaften
    |July 1, 1976
    PubMed
    Summary
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    Mutations and external factors can disrupt brain development during critical periods. Understanding these mechanisms is key to preventing and treating minimal organic brain damage in children.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Pediatrics

    Background:

    • Cerebral structure development and differentiation are susceptible to mutations and external factors (exogenous noxae).
    • The brain is highly sensitive to exogenous noxae during the crucial period from the tenth week of gestation to the tenth year of life.
    • Basic research has elucidated mechanisms of normal brain development and identified factors potentially disrupting these regulatory processes.

    Purpose of the Study:

    • To explore the mechanisms underlying cerebral development and its disorders.
    • To investigate the potential link between disorders of cerebral development and minimal organic brain damage.
    • To highlight the necessity of integrating basic and clinical research for advancing understanding and clinical applications.

    Main Methods:

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    • Review of basic research findings on normal brain development mechanisms.
    • Analysis of factors associated with disturbances in regulatory processes.
    • Conceptual framework linking developmental disorders to potential neurological conditions.

    Main Results:

    • Identified critical developmental periods highly sensitive to external influences.
    • Discovered regulatory mechanisms governing normal brain development.
    • Proposed potential links between cerebral developmental disorders and minimal organic brain damage, requiring further investigation.

    Conclusions:

    • Disorders in cerebral development, influenced by genetic and environmental factors, can occur during sensitive early life stages.
    • While a link is suggested, further research is needed to confirm the association between cerebral developmental disorders and minimal organic brain damage.
    • Enhanced collaboration between basic science and clinical practice is essential for advancing the prevention, diagnosis, and treatment of infantile minimal organic brain damage.