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Related Experiment Videos

Small intestinal transit in diabetics

J H Scarpello, M Greaves, G E Sladen

    British Medical Journal
    |November 20, 1976
    PubMed
    Summary

    Diabetic autonomic neuropathy significantly slows small intestinal transit, potentially causing bacterial overgrowth and diarrhea. This lactulose breath test assesses gastrointestinal motility in diabetes.

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    Area of Science:

    • Gastroenterology
    • Diabetology
    • Neurology

    Background:

    • Diabetes mellitus can affect gastrointestinal function.
    • Autonomic neuropathy is a common complication of diabetes.
    • Altered small intestinal transit is implicated in diabetic gastrointestinal symptoms.

    Purpose of the Study:

    • To assess small intestinal transit time in diabetic patients compared to healthy controls.
    • To investigate the impact of autonomic neuropathy on small intestinal transit in diabetes.
    • To explore the potential link between delayed transit and diarrhea in diabetic individuals.

    Main Methods:

    • Lactulose breath hydrogen appearance time was measured.
    • Small intestinal transit was assessed in diabetic patients (with and without autonomic neuropathy) and healthy controls.

    Main Results:

    • Small intestinal transit was significantly slower in diabetic patients with autonomic neuropathy compared to those without neuropathy and healthy controls.
    • Delayed transit is likely attributed to vagal denervation in diabetic patients.
    • Slower transit times may facilitate bacterial proliferation, potentially explaining diarrhea in some diabetics.

    Conclusions:

    • Autonomic neuropathy significantly delays small intestinal transit in diabetic patients.
    • Delayed transit and subsequent bacterial proliferation may contribute to diarrhea in diabetes.
    • The lactulose breath test is a valuable tool for assessing small intestinal transit in diabetes, but requires caution in patients with existing small bowel bacterial overgrowth.

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