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Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium
T S Stappenbeck1, M H Wong, J R Saam
1Department of Molecular Biology and Pharmacology Washington University School of Medicine St. Louis MO 63110 USA.
Current Opinion in Cell Biology
|January 23, 1999
Abstract:
The mouse intestinal epithelium undergoes rapid renewal throughout life, thereby requiring continuous coordination of its cellular proliferation, differentiation, and death programs. Recent advances in our understanding of this process have highlighted some of the molecules that regulate renewal and their potential roles in gut neoplasia.