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Related Experiment Videos

Mitotic DNA damage and replication checkpoints in yeast

N Rhind1, P Russell

  • 1The Scripps Research Institute 10550 Torrey Pines Road La Jolla CA 92037 USA.

Current Opinion in Cell Biology
|January 23, 1999
PubMed
Summary

Budding and fission yeast genetics have defined cell cycle checkpoint biology. Recent biochemical studies reveal how checkpoint proteins target normal cell cycle machinery.

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Area of Science:

  • Cell Biology
  • Genetics
  • Biochemistry

Background:

  • Budding and fission yeasts are model organisms for studying cell cycle regulation.
  • Genetic studies in these yeasts have been foundational in establishing cell cycle checkpoint concepts.

Purpose of the Study:

  • To elucidate the genetic underpinnings of G2/M checkpoints.
  • To understand the biochemical mechanisms of checkpoint gene products.

Main Methods:

  • Genetic analysis in yeast models.
  • Biochemical characterization of checkpoint proteins.

Main Results:

  • Established key concepts in checkpoint biology through yeast genetics.
  • Identified specific cell cycle machinery components targeted by checkpoints via biochemical approaches.

Conclusions:

  • Yeast genetics provides fundamental insights into cell cycle checkpoints.
  • Biochemistry is revealing the precise molecular mechanisms of checkpoint control.

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