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Hydrophobic core packing and protein design
1Department of Molecular and Cell Biology 229 Stanley Hall University of California at Berkeley Berkeley CA 94720 USA.
Current Opinion in Chemical Biology
|January 23, 1999
Summary
Recent protein design advances show computational design of functional proteins is increasingly feasible. Successful hydrophobic core and full sequence designs pave the way for creating larger, complex protein structures.
Area of Science:
- Biochemistry
- Structural Biology
- Computational Biology
Background:
- Significant progress has been made in computational protein design.
- Previous successes include the design of hydrophobic cores.
Purpose of the Study:
- To review recent advances in protein design.
- To highlight the feasibility of designing large, functional proteins computationally.
Main Methods:
- Application of hydrophobic core design principles.
- Full sequence design of small protein motifs.
- Design of catalytically active metal centers.
Main Results:
- Demonstrated success in designing hydrophobic cores.
- Successful full sequence design of a small protein motif.
- Successful design of a catalytically active metal center.
Conclusions:
- Computational protein design has advanced significantly.
- Designing large, functional proteins in silico is becoming increasingly achievable.