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The genetic and molecular mechanisms of motor neuron disease
P C Wong1, J D Rothstein, D L Price
1Department of Pathology, Division of Neuropathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205-2196, USA. pcwong@welchlink.welch.jhu.edu
Current Opinion in Neurobiology
|January 23, 1999
Abstract:
Significant progress has been made in the identification of genes and chromosomal loci associated with several types of motor neuron disease. Of particular interest is recent work on the pathogenic mechanisms underlying these diseases, especially studies in in vitro model systems and in transgenic and gene-targeted mice.