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Three-dimensional structural studies on fragments of fibrinogen and fibrin
R F Doolittle1, G Spraggon, S J Everse
1Center for Molecular Genetics University of California San Diego La Jolla CA 92093-0634 USA. rdoolittle@ucsd.edu
Current Opinion in Structural Biology
|January 23, 1999
Abstract:
Fibrinogen is a 340 kDa glycoprotein found in the blood plasma of all vertebrates. It is transformed into a fibrin clot by the action of thrombin. Recent X-ray structures of core fragments of both fibrinogen and fibrin have revealed many details about this polymerization event. These include structures of a 30 kDa recombinant gammaC domain, an 86 kDa fragment D from human fibrinogen and a cross-linked double-D fragment from fibrin.