Conformational changes and disease--serpins, prions and Alzheimer's
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Updated: Oct 26, 2026

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material
Published on: September 29, 2017
1Department of Haematology Cambridge Institute for Medical Research University of Cambridge Hills Road Cambridge CB2 2XY UK. rwc 1000@cam.ac.uk
Abstract:
Some of the most perplexing disorders in medicine are each now known to arise from the conformational instability of an underlying protein. The consequence is a continuum of pathologies with typically a change in fold leading to ordered aggregation and tissue deposition. The serpins provide a structural prototype for these pathologies and give a perspective on the assessment of current proposals as to the conformational basis of both Alzheimer's disease and the transmissible prion encephalopathies.
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