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Factors affecting peak bone density in Japanese women
Y Fujita1, K Katsumata, A Unno
1Department of Pediatrics, Juntendo University School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113, Japan.
Calcified Tissue International
|January 23, 1999
Summary
Peak bone mass in women is influenced by genetics and lifestyle. Exercise and menstrual history significantly impact bone mineral density (BMD), regardless of vitamin D receptor (VDR) genotype.
Area of Science:
- Bone biology and genetics
- Women's health and endocrinology
Background:
- Bone mineral density (BMD) is determined by both genetic and environmental factors.
- Understanding gene-environment interactions is crucial for optimizing peak bone mass.
- Previous research suggests a role for lifestyle and genetics in bone health.
Purpose of the Study:
- To investigate the interplay between genetic factors (VDR genotype) and environmental influences on peak bone mass in young women.
- To identify key predictors of bone mineral density (BMD) among lifestyle and genetic variables.
Main Methods:
- Cross-sectional study involving 157 healthy young Japanese women.
- Assessed bone mineral density (BMD) in relation to physical constitution, vitamin D receptor (VDR) genotype, age, age of menarche, menstrual dysfunction history, and exercise history.
Main Results:
- History of exercise and menstrual dysfunction were identified as significant independent predictors of BMD.
- Vitamin D receptor (VDR) genotype was found to influence peak bone density.
- Exercise demonstrated a positive effect on BMD across all VDR genotypes, including those associated with lower bone density.
Conclusions:
- Complex gene-environment interactions, particularly involving menstrual history, exercise, and genetic factors during adolescence, influence adult BMD in women.
- Lifestyle interventions like exercise can positively impact bone density, even in individuals with genetic predispositions for lower bone mass.