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Synchronous bilateral Wilms' tumor

A Nawaz¹, C Mpofu, R Shawis

¹Division of Paediatric Surgery, Department of Surgery, Tawam Hospital, Al Ain, Abu Dhabi, United Arab Emirates.

Pediatric Surgery International

|January 23, 1999

Summary

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Synchronous bilateral Wilms

Area of Science:

Pediatric Oncology
Nephrology

Background:

Synchronous bilateral Wilms' tumor (WT) represents 5% of all WT cases globally.
A study of 34 WT cases revealed 7 (20.6%) bilateral cases, with a male predominance in 5 instances.
Observed high bilaterality and male preponderance may indicate regional variations in Wilms' tumor presentation.

Purpose of the Study:

To report the diagnosis, therapy, and outcomes of synchronous bilateral Wilms' tumor.
To investigate potential regional variations in Wilms' tumor characteristics.

Main Methods:

Retrospective analysis of 34 Wilms' tumor cases treated.
Detailed review of diagnostic procedures.
Evaluation of therapeutic strategies, including preoperative chemotherapy.
Assessment of patient outcomes.

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Main Results:

Seven out of 34 (20.6%) Wilms' tumor cases were bilateral.
Five of the bilateral cases occurred in males, indicating a male preponderance.
The frequency of bilaterality and male predominance in this series differed from international reports.

Conclusions:

The findings suggest possible regional variations in the epidemiology of Wilms' tumor.
Further research is warranted to understand the factors contributing to these observed differences.