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Cell adhesion molecules in normal laryngeal development

A M Soliman1, R M Jones, P W Flint

  • 1Department of Otorhinolaryngology and Bronchoesophagology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 23, 1999
PubMed
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Neural cell adhesion molecules are crucial for larynx development in rats, appearing during embryonic stages and decreasing after birth. These findings highlight their role in neural development of the larynx.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Anatomy

Background:

  • Neural cell adhesion molecules (NCAMs) are vital for neuronal development and cell interactions.
  • Understanding the role of NCAMs in larynx development is essential for comprehending neural pathway formation.

Purpose of the Study:

  • To investigate the expression and role of neural cell adhesion molecules (NCAMs) during rat larynx development.
  • To determine the temporal and spatial distribution of NCAMs in relation to the recurrent laryngeal nerve.

Main Methods:

  • Immunohistochemical techniques were used to analyze larynx sections from embryonic day 10 to adult rats.
  • Primary antibodies targeting NCAM, polysialylated NCAM (PSA-NCAM), and L1 were employed.

Main Results:

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  • NCAMs were detected throughout embryonic larynx development, particularly along the recurrent laryngeal nerve.
  • A significant downregulation of NCAM expression was observed after postnatal day 14.
  • L1 expression patterns also indicated a role in neural development.

Conclusions:

  • Neural cell adhesion molecules are implicated in the normal neural development of the rat larynx.
  • The observed downregulation suggests a critical period for NCAM involvement in larynx innervation.