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Genetic amniocentesis after multifetal pregnancy reduction
1Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, New York 10029, USA.
American Journal of Obstetrics and Gynecology
|January 23, 1999
Summary
Genetic amniocentesis after multifetal pregnancy reduction did not increase pregnancy loss rates. This study found similar pregnancy loss risks in patients who underwent the procedure compared to those who did not.
Area of Science:
- Reproductive Medicine
- Maternal-Fetal Medicine
- Genetics
Background:
- Multifetal pregnancy reduction (MFPR) is a procedure to decrease the number of fetuses.
- Genetic amniocentesis is a diagnostic test performed during pregnancy.
Purpose of the Study:
- To evaluate the pregnancy loss rate following genetic amniocentesis in patients who have undergone multifetal pregnancy reduction.
Main Methods:
- A cohort study compared 127 patients undergoing genetic amniocentesis post-MFPR with 167 controls who did not have amniocentesis.
- Maternal age over 30 years was a criterion for inclusion.
Main Results:
- Pregnancy loss rate was 3.1% in the study group versus 7.2% in the control group (P > 0.05).
- Infection was noted in only one case, occurring one day post-amniocentesis.
- Other pregnancy losses occurred later and were not directly attributed to either procedure.
Conclusions:
- Genetic amniocentesis after MFPR does not appear to elevate the risk of pregnancy loss.
- The findings suggest the procedure is safe in this context.