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Accuracy of salivary estriol testing compared to traditional risk factor assessment in predicting preterm birth
R P Heine1, J A McGregor, V K Dullien
1University of Pittsburgh, Pennsylvania 15213, USA.
Objective:
The objective was to compare the predictive accuracy (percentage of correct vs incorrect predictions) of salivary estriol levels (SalEst; Biex, Inc, Dublin, Calif) with that of the modified Creasy score for predicting preterm labor followed by preterm delivery.
Study Design:
A triple-blinded prospective trial was conducted at 8 US centers.
Results:
Among 601 evaluable patients, serial salivary estriol testing correctly predicted the appropriate outcome 91% of the time and the Creasy scoring method correctly predicted the appropriate outcome 75% of the time (McNemar test P <. 001). Among subjects with Creasy scores >/=10 (high-risk group, n = 152), use of salivary estriol testing correctly predicted the end point 87% of the time, compared with only 7.2% correctly predicted by modified Creasy scoring (McNemar test P <.001).
Conclusion:
Salivary estriol assessment was more accurate in predicting outcome than was modified Creasy scoring.