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T-cell receptors in ectothermic vertebrates
J Charlemagne1, J S Fellah, A De Guerra
1Groupe d'Immunologie Comparée, Université Pierre et Marie Curie, Paris, France. jcharlem@snv.jussieu.fr
Immunological Reviews
|January 23, 1999
Summary
The structure of T-cell receptors (TCR) and MHC molecules is highly conserved across vertebrate evolution, indicating strong selective pressure. This conservation ensures the proper functioning of adaptive immunity in diverse species.
Area of Science:
- Immunology
- Evolutionary Biology
- Molecular Biology
Background:
- T-cell receptors (TCR) are crucial for adaptive immunity.
- Understanding TCR structure and function in diverse vertebrates provides insights into immune system evolution.
Purpose of the Study:
- To investigate the structure and gene expression of T-cell receptor (TCR)-like molecules in ectothermic vertebrates.
- To compare the evolutionary conservation of TCR and MHC molecules across jawed vertebrates.
Main Methods:
- Analysis of gene structure and expression patterns of TCR-like molecules.
- Phylogenetic comparison of TCR and MHC class I and II molecules.
Main Results:
- TCR beta- and alpha-like chains are conserved across chondrychthians, teleosts, and amphibians.
- TCR gamma- and delta-like chains were found in a chondrychthian species.
- Variable (V), joining (J), and diversity (D) segments contribute to TCR diversity, with N- and P-nucleotide additions at junctions.
- MHC class I and II molecules are also conserved in jawed vertebrates.
Conclusions:
- The structure and diversity potential of TCR molecules have been conserved due to selective pressure throughout vertebrate evolution.
- The functional linkage between TCR and MHC molecules has led to their reciprocal evolutionary conservation, ensuring effective immune responses.