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Subversion of cytokine networks by viruses
1Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
International Reviews of Immunology
|January 23, 1999
Summary
Viruses have evolved immune evasion strategies, particularly by disrupting immune system communication. This review examines viral immune modulators from poxviruses, adenoviruses, and herpesviruses.
Area of Science:
- Virology
- Immunology
- Molecular Biology
Background:
- Viruses and host immune systems engage in a continuous co-evolutionary battle.
- Viruses have developed diverse mechanisms to evade immune system clearance.
- Understanding viral strategies offers insights into immune function and host-pathogen interactions.
Purpose of the Study:
- To review viral immune-modulating gene products.
- To highlight how viruses subvert host immune responses.
- To focus on specific viral families: poxviruses, adenoviruses, and herpesviruses.
Main Methods:
- Literature review of viral immune evasion strategies.
- Analysis of viral gene products that modulate host immunity.
- Focus on disruption of cytokine networks and immune signaling pathways.
Main Results:
- Viruses effectively block immune system communication channels.
- Viral proteins are adept at targeting cytokine networks.
- Poxviruses, adenoviruses, and herpesviruses encode key immune-modulatory proteins.
Conclusions:
- Viral immune modulators are crucial for viral survival and pathogenesis.
- Studying these viral proteins illuminates complex virus-host interactions.
- Targeting viral immune evasion offers potential therapeutic avenues.