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Cytokines in autoimmune disorders

M Feldmann1, F M Brennan, R Maini

  • 1Kennedy Institute of Rheumatology, Hammersmith, London, UK.

International Reviews of Immunology
|January 23, 1999
PubMed
Summary

Cytokines are key protein mediators in immunity and inflammation. Targeting tumor necrosis factor-alpha (TNF) has shown significant therapeutic success in treating autoimmune diseases like rheumatoid arthritis and Crohn

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Area of Science:

  • Immunology and molecular biology
  • Study of protein mediators in biological processes

Background:

  • Cytokines are crucial protein mediators involved in immunity, inflammation, cell proliferation, differentiation, and fibrosis.
  • Growing evidence implicates cytokines in the pathogenesis of autoimmune diseases.
  • Significant advancements have been made in understanding cytokine function, gene cloning, and receptor interactions.

Purpose of the Study:

  • To highlight the critical role of cytokines in autoimmunity.
  • To discuss the progress in understanding cytokine mechanisms and signaling.
  • To demonstrate the therapeutic potential of targeting cytokines in autoimmune diseases.

Main Methods:

  • Review of scientific literature on cytokines and autoimmunity.
  • Analysis of molecular cloning data for cytokines and their receptors.
  • Examination of therapeutic strategies targeting cytokine pathways.

Main Results:

  • Cytokines play a significant role in the pathogenesis of autoimmune conditions.
  • Molecular cloning has advanced the understanding of cytokine structure and function.
  • Blocking tumor necrosis factor-alpha (TNF) has proven effective in treating rheumatoid arthritis and Crohn's disease.

Conclusions:

  • Cytokines are integral to autoimmune disease development.
  • Targeting specific cytokines, such as TNF-alpha, offers a validated therapeutic approach for autoimmune disorders.
  • Continued research into cytokine signaling promises further advancements in treating autoimmune diseases.

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