Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone morphogenesis and surface charge

C Eriksson

    Clinical Orthopaedics and Related Research
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Bone morphogenetic activity is linked to a negative surface charge on implants, crucial for cell adhesion and differentiation. Increasing this negative charge enhances bone regeneration potential.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Real-World Outcomes of Patients Starting Intravenous and Transitioning to Subcutaneous Vedolizumab in Inflammatory Bowel Disease.

    Digestive diseases and sciences·2024
    Same author

    Anti-Saccharomyces cerevisiae Antibodies Are Only Modestly More Common in Subjects Later Developing Crohn's Disease.

    Digestive diseases and sciences·2022
    Same author

    Urban residential greenness and adiposity: A cohort study in Stockholm County.

    Environment international·2018
    Same author

    IgG4 anti-infliximab in treated patients: Clinical impact and temporal evolution.

    Allergy·2018
    Same author

    Concentrations of infliximab and anti-drug antibodies in relation to clinical response in patients with rheumatoid arthritis.

    Scandinavian journal of rheumatology·2018
    Same author

    Editorial: do thiopurines and biologics decrease the risk of colectomy? Authors' reply.

    Alimentary pharmacology & therapeutics·2017
    Same journal

    Impact Microindentation Evaluates Bone Strength, Bone Quality, and Fracture Susceptibility Across Skeletal Sites: A Cadaver Study.

    Clinical orthopaedics and related research·2026
    Same journal

    What Is the Effect of Robot Reduction in Displaced Pelvic Fractures? A Multicenter Randomized Clinical Trial.

    Clinical orthopaedics and related research·2026
    Same journal

    CORR Insights®: Acute or Delayed TKA for Tibial Plateau Fracture? An Observational Study From the Swedish Arthroplasty Register.

    Clinical orthopaedics and related research·2026
    Same journal

    Reply to the Letter to the Editor: Guest Editorial: Recalling a Recall.

    Clinical orthopaedics and related research·2026
    Same journal

    Radial Head Fractures Cluster in the Anterolateral and Anteromedial Quadrants and Do Not Correlate With Coronoid Fracture Types.

    Clinical orthopaedics and related research·2026
    Same journal

    Reduced Cerebellar Activation With Eyes Closed Is Associated With Delayed Peroneal Reaction Time in Patients With Chronic Ankle Instability.

    Clinical orthopaedics and related research·2026
    See all related articles

    Area of Science:

    • Biomaterials Science
    • Orthopedic Research
    • Cell Biology

    Background:

    • Bone morphogenetic activity is essential for bone regeneration.
    • The surface properties of bone implants influence cellular interactions.
    • Understanding the biophysical interactions at the implant-tissue interface is critical.

    Purpose of the Study:

    • To investigate the relationship between bone implant surface charge and morphogenetic activity.
    • To determine the optimal surface charge for mesenchymal cell adhesion and differentiation.
    • To elucidate the role of surface charge in bone inductive processes.

    Main Methods:

    • Electrophoretic mobility measurements of variously treated bone specimens.
    • Assessment of bone morphogenetic activity in physiological solutions.

    Related Experiment Videos

  • Analysis of surface charge effects on mesenchymal cell interactions with implants.

    • Main Results:

    • Bone morphogenetic activity correlates with a minimum negative surface charge, similar to normal cortical bone.
    • Demineralization of bone in HCl increases negative surface charge and enhances morphogenetic activity.
    • Negative surface charge facilitates close contact between implants and negatively charged mesenchymal cells.

    Conclusions:

    • A sufficient negative surface charge on bone implants is critical for promoting mesenchymal cell adhesion and subsequent differentiation.
    • Optimizing implant surface charge can enhance bone regeneration by improving cellular interactions.
    • The findings suggest a biophysical mechanism for bone induction mediated by surface charge interactions.