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Related Experiment Videos

Dialyzer-dependent changes in solute and water permeability with bleach reprocessing

M K Scott1, B A Mueller, K M Sowinski

  • 1Department of Pharmacy Practice, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, USA. mkscott@iupui.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|January 23, 1999
PubMed
Summary

Bleach reprocessing significantly increases the permeability of high-flux dialyzers, affecting solute removal. This effect is more pronounced in polysulfone membranes, potentially compromising the removal of larger solutes after multiple reuses.

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Area of Science:

  • Nephrology
  • Biomaterials Science
  • Chemical Engineering

Background:

  • Dialyzer reprocessing is common practice to reduce costs.
  • The impact of bleach/formaldehyde reprocessing on high-flux dialyzer performance requires detailed characterization.
  • Cellulose triacetate (CT190) and polysulfone (F80B) dialyzers are widely used.

Purpose of the Study:

  • To comprehensively characterize the effects of automated bleach/formaldehyde reprocessing on solute and hydraulic permeability of CT190 and F80B dialyzers.
  • To compare the performance changes of CT190 and F80B dialyzers after repeated reuse cycles.

Main Methods:

  • An in vitro model was used to evaluate dialyzer performance.
  • Dialyzers (CT190 and F80B) were tested after 0, 1, 5, 10, and 15 reuse cycles (R0-R15).

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  • Key performance metrics included ultrafiltration coefficient (Kuf), serial clearances, and sieving coefficients (SCs) for various solutes (urea, creatinine, vancomycin, inulin, myoglobin, albumin).

    • Main Results:

    • Urea, creatinine, and vancomycin clearances/SCs remained stable for both dialyzers across all reuses.
    • Inulin clearance/SC increased significantly for F80B but not CT190 after 15 reuses.
    • Myoglobin clearance and albumin SC significantly increased for both dialyzers, with CT190 showing higher myoglobin clearance.
    • Ultrafiltration coefficient (Kuf) significantly increased for F80B but not CT190 after 15 reuses.

    Conclusions:

    • Bleach reprocessing significantly enhances the hydraulic and larger solute permeability of both CT190 and F80B high-flux dialyzers.
    • The polysulfone (F80B) membrane exhibits a more pronounced increase in permeability compared to the cellulose triacetate (CT190) membrane.
    • The removal of solutes >1,500 Da may be compromised in F80B dialyzers after 10 or more reuses.