Related Experiment Video
Updated: Feb 14, 2026
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
17.2K
DNA microarrays in drug discovery and development
1SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.
Nature Genetics
|January 23, 1999
Summary
DNA microarrays enable parallel measurement of gene expression, aiding in the identification of therapeutic targets and monitoring drug treatment responses. This technology significantly impacts drug discovery processes.
Area of Science:
- Genomics and Molecular Biology
- Pharmacology and Drug Discovery
Background:
- DNA microarrays allow for high-throughput analysis of gene expression.
- Understanding gene expression patterns is crucial for identifying drug targets and evaluating drug efficacy.
Purpose of the Study:
- To discuss the impact of DNA microarray analysis on drug discovery.
- To highlight the applications of microarrays in identifying therapeutic targets and monitoring drug responses.
Main Methods:
- Gene expression profiling using DNA microarrays.
- Analysis of large-scale gene expression data.
Main Results:
- Microarray analysis provides insights into gene function.
- Identifies potential therapeutic targets through parallel gene expression measurement.
- Enables monitoring of gene expression changes in response to drug treatments.
Conclusions:
- DNA microarrays are a powerful tool revolutionizing drug discovery.
- Facilitates target identification and drug response monitoring, accelerating therapeutic development.
Related Concept Videos
01:10In Vitro Drug Release Testing: Overview, Development and Validation
368
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
368
02:34DNA Microarrays
21.3K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
21.3K
01:26Drug Discovery: Overview
11.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.9K
02:02DNA Topoisomerases
35.9K
Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
35.9K
00:55DNA Helicases
24.2K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.2K
01:09Recombinant DNA
103.5K
Overview
103.5K