The changes in the nervous structures under the chemical sympathectomy with guanethidine

The process of sympathectomy of white rats was achieved by injecting guanethidine intraperitoneally every day for 5.5 weeks at doses of 75 mg/kg of animal's weight. This process of sympathectomy was checked according to ganglion cervicothoracicum neurocytes state. The material was taken on days 1, 14, 30, 90 and 180 after cessation of guanethidine injections. It was ascertained that full sympathectomy under prolonged injections of high doses of guanethidine is reached at 5-6 months after the cessation of the injections, though pronounced total degeneration of gnl. stellatum neurocytes is marked on the 14th-30th days after cessation of the guanethidine injections. The following gradient of damaging influence of guanethidine was revealed: sympathetic gnl. cervicothoracicum neurocytes gnl. nodosum afferent neurocytes-neuromuscular synapsis skeletal muscle.