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An action plan for mouse genomics

J Battey1, E Jordan, D Cox

  • 1National Institute on Deafness and Other Communication Disorders, NIH Building 31, Bethesda, Maryland 20892, USA. batteyj@nidcd.nih.gov

Nature Genetics
|January 23, 1999
PubMed
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The mouse is a key mammal research model. New genomic and genetic resources, including a mouse genome sequence, will enhance its utility for scientific discovery.

Area of Science:

  • Mammalian genetics and genomics
  • Animal models in biomedical research

Background:

  • The laboratory mouse is the predominant animal model for studying mammalian biology.
  • Enhancing genetic and genomic resources is crucial for expanding the mouse model's research applications.

Purpose of the Study:

  • To outline plans for developing new resources to improve the mouse as a research model.
  • To support the generation of a mouse genome 'working draft' sequence and establish specialized centers.

Main Methods:

  • National Institutes of Health (NIH) funding initiatives.
  • Community-driven recommendations for resource development.
  • Establishment of mutagenesis and phenotyping centers.
  • Development of repositories for mouse strain maintenance, distribution, and cryopreservation.

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  • Creation of training fellowships in mouse pathobiology.

    • Main Results:

    • A strategic plan to significantly enhance the mouse as a model organism.
    • Anticipated completion of a 'working draft' mouse genome sequence by 2003.
    • Establishment of infrastructure for systematic genetic manipulation and characterization.
    • Improved accessibility and preservation of mouse strains for researchers worldwide.

    Conclusions:

    • These initiatives will greatly increase the mouse model's value to the research community.
    • The development of comprehensive genomic and genetic resources is essential for advancing mammalian biology research.