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Updated: Aug 16, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Expansile bone lesions in a three-generation family
M B Dinulos1, D L Sternen, C B Graham
1Department of Pediatrics, University of Washington School of Medicine and Children's Hospital and Regional Medical Center, Seattle 98105, USA.
Abstract:
We report on a three-generation family with "expansile" bone lesions of the distal radius and ulna, cortical thickening of the proximal long bones, and pathologic fractures. The differential diagnosis of expansile bone lesions includes isolated bone cysts and tumors, such as enchondromas and fibrous dysplasia; familial expansile osteolysis; and the genochondromatoses. Our patients have findings most similar to the genochondromatoses; however, the distribution of the lesions and the accompanying manifestations may be evidence for a unique genetic condition in this family.
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